RSS newsfeed: Glandular fever

AbstractWe performed a pooled analysis of data on self‐reported history of infections in relation to the risk of non‐Hodgkin lymphoma (NHL) from 17 case‐control studies that included 12,585 cases and 15,416 controls aged 16‐96 years at recruitment. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were estimated in two‐stage random‐effect or joint fixed‐effect models, adjusting for age, sex and study centre. Data from the two years prior to diagnosis (or date of interview for controls) were excluded. A self‐reported history of infectious mononucleosis (IM) was associated with an excess risk of NHL (OR=1.26, 95% CI=1.01‐1.57 based on data from 16 studies); study‐specific results indicate significant (I2=51%, p=0.01) heterogeneity. A self‐reported history of...

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Authors: Michelow P, Wright C, Pantanowitz L Abstract The Epstein-Barr virus (EBV) is a member of the herpes family of viruses and is very common in humans. EBV is most often associated with infectious mononucleosis. However, it is estimated that 1% of tumors including lymphoproliferative, epithelial and mesenchymal are linked to EBV infection. EBV has a tropism for certain epithelial cells, lymphocytes and myocytes. Like other herpesviruses, EBV has both lytic and latent phases of infection. In the latent form, EBV-encoded genes ensure the survival of the viral genome, allowing it to circumvent the host's immune surveillance by limited expression of viral proteins and carries with it the risk of neoplastic transformation. Cytologists are likely to encounter EBV-associated malignan...

Epstein-Barr virus causes glandular fever, but could also damage brain cells, causing the symptoms of multiple sclerosis (Source: New Scientist - Health)

Summary: A vascular condition called chronic cerebrospinal venous insufficiency (CCSVI), which has attracted global attention as possibly being correlated with MS has, for the first time, been studied for the presence of risk factors in subjects who do not have a neurological disease. A preliminary University at Buffalo study of 252 volunteers has found an association between CCSVI and as many as three characteristics widely viewed as possible or confirmed MS risk factors. They are: infectious mononucleosis, irritable bowel syndrome and smoking... (Source: Health News from Medical News Today)

Authors: Joo EJ, Ha YE, Jung DS, Cheong HS, Wi YM, Song JH, Peck KR Abstract Chronic active Epstein-Barr virus (CAEBV) infection is characterized by persistent infectious mononucleosis-like symptoms, an unusual pattern of Epstein-Barr virus (EBV) antibodies, detection of the EBV genome in affected tissues or peripheral blood, and chronic illness that cannot be attributed to any other known disease. This is the first reported Korean case of an immunocompetent adult with CAEBV-associated interstitial pneumonitis. A 28-year-old female was admitted with a fever that persisted for 3 weeks. She had multiple lymphadenopathy, hepatosplenomegaly, pancytopenia, and elevated serum aminotransferase levels. Serology for antibodies was positive and chest computed tomography showed diffuse ground...

[Aman with persisting fever, night sweats and high sedimentation rate]. Tidsskr Nor Laegeforen. 2011 Nov 29;131(23):2362-5 Authors: Kildahl-Andersen O, Murbræch K, Skudal H, Stalsberg H Abstract Background. Fever of unknown origin and high sedimentation rate are common clinical problems. Material and methods. A middle-aged man with fever of unknown origin, night sweats and high sedimentation rate was referred to our hospital for investigation. Results and interpretation.The patient was suspected to have mononucleosis or reactivation of infectious mononucleosis because of mild anaemia and thrombocytopenia, a weakly postive IgM antibody test for Epstein-Barr virus and monocytosis (in peripheral blood). Because monocytosis, elevated sedimentation rate and fever persisted, bon...

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The Epstein-Barr virus is responsible for infectious mononucleosis syndrome and is also closely associated to several types of cancer. The main complication involving Epstein-Barr virus infection, both in recipients of hematopoietic stem cells and solid organs, is post-transplant lymphoproliferative disease. The importance of this disease has increased interest in the development of laboratory tools to improve post-transplant monitoring and to detect the disease before clinical evolution. Viral load analysis for Epstein-Barr virus through real-time polymerase chain reaction is, at present, the best tool to measure viral load. However, there is not a consensus on which sample type is the best for the test and what is its predictive value for therapeutic interventions. (Source: Revista Brasi...

Authors: Okano M, Gross TG Abstract Infectious mononucleosis (IM) is one of the representative, usually benign, acute diseases associated with primary Epstein-Barr virus (EBV) infection. IM is generally self-limiting and is characterized mostly by transient fever, lymphadenopathy and hepatosplenomegaly. However, very rarely primary EBV infection results in severe or fatal conditions such as hemophagocytic lymphohistiocytosis together with fulminant hepatitis designated as severe or fatal IM or EBV-associated hemophagocytic lymphohistiocytosis alone. In addition, chronic EBV-associated diseases include Burkitt's lymphoma, undifferentiated nasopharyngeal carcinoma, Hodgkin lymphoma, T-cell lymphoproliferative disorder (LPD)/lymphoma, natural killer-cell LPD including leukemia or lymp...

Epstein-Barr virus (EBV) infects nine out of ten people worldwide at some point during their lifetimes. Infections in early childhood often cause no disease symptoms, but people infected during adolescence or young adulthood may develop infectious mononucleosis, a disease characterized by swollen lymph nodes, fever and severe fatigue. EBV also is associated with several kinds of cancer, including Hodgkin lymphoma and stomach and nasal cancers... (Source: Health News from Medical News Today)

Conclusion: In a study that controls for confounders, our data focus an EBNA-1 specificity that may be associated with MS pathogenesis. (Source: Multiple Sclerosis)

(NIH/National Institute of Allergy and Infectious Diseases) Epstein-Barr virus infects nine out of ten people worldwide at some point during their lifetimes. Infections in early childhood often cause no disease symptoms, but people infected during adolescence or young adulthood may develop infectious mononucleosis, a disease characterized by swollen lymph nodes, fever and severe fatigue. (Source: EurekAlert! - Medicine and Health)

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