Recent journal publications

CONCLUSION: Specific colonoscopic findings in patients with UC complicated by CMV infection were identified. These findings may facilitate the early diagnosis of CMV infection in UC patients. PMID: 20222169 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Roughly 16% of U.S. residents ages 14 through 49 are infected with genital herpes, making it one of the nation's most common sexually transmitted infections, according to a Centers for Disease Control and Prevention analysis released on Tuesday, Reuters reports. CDC noted that infection rates for the lifelong and incurable infection varied by gender and race. Twenty-one percent of U.S... (Source: Women's Health / OBGYN News From Medical News Today)

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Roughly 16% of U.S. residents ages 14 through 49 are infected with genital herpes, making it one of the nation's most common sexually transmitted infections, according to a Centers for Disease Control and Prevention analysis released on Tuesday, Reuters reports. CDC noted that infection rates for the lifelong and incurable infection varied by gender and race. Twenty-one percent of U.S. women are infected with genital herpes, compared with 11.5% of men. Blacks have a 39% infection rate, compared with 12% among whites... (Source: Health News from Medical News Today)

Monoclonal antibodies may be used more effectively in combination. A previous study of intravenous (iv) bolus alemtuzumab plus rituximab in patients with chronic lymphocytic leukemia (CLL) recurrence produced a response rate of 54% after a 4-week treatment period.To optimize dose, schedule, and route of alemtuzumab, a study was designed exploring continuous intravenous infusion (civ) followed by subcutaneous (sc) alemtuzumab together with weekly iv rituximab in patients with previously treated CLL.Data from 40 patients with a median age of 59 years, and a median of 3 prior regimens (range, 1-8 regimens) were evaluable. Approximately 64% of patients were fludarabine-refractory. Seven patients (18%) achieved a complete response (CR), 4 (10%) a nodular partial response (nPR), and 10 (25%) a p...

Online screening tools for depression or anxiety; risks of longtime osteoporosis medicine use. (Source: U.S. News - Health)

As much as 16 percent of the U.S. population between the ages of 14 and 49 has genital herpes, according to a government study released Tuesday. (Source: CNN.com - Health)

A vaccine is available - why don't we use it? (Source: BBC News | Health | UK Edition)

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Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, announced the initiation of a multi-center Phase 2 clinical trial designed to evaluate CMX001 in stem cell transplant recipients who are seropositive for cytomegalovirus (CMV). CMX001 is a broad-spectrum antiviral agent with demonstrated activity against double-stranded DNA (dsDNA) viruses... (Source: Health News from Medical News Today)

Chimerix, Inc., a biotechnology company developing orally-available antiviral therapeutics, announced the initiation of a multi-center Phase 2 clinical trial designed to evaluate CMX001 in stem cell transplant recipients who are seropositive for cytomegalovirus (CMV). CMX001 is a broad-spectrum antiviral agent with demonstrated activity against double-stranded DNA (dsDNA) viruses... (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)

The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Acyclovir suppressive therapy (400 mg twice daily) reduces herpes simplex virus (HSV) type 2–associated genital ulcer disease and lesional HSV shedding. In an international trial of acyclovir for suppression of HSV type 2 to prevent human immunodeficiency virus (HIV) acquisition (HIV Prevention Trials Network 039), acyclovir had a smaller effect on the frequency of genital ulcer disease as well as a smaller effect on the frequency and quantity of lesional HSV DNA in African women and Peruvian men, compared with its effects in men in the United States. The observed regional variation in the clinical and virologic efficacy of acyclovir for HSV suppression warrants further evaluation of determinants of r...

Title: CDC: Genital Herpes Rates Still HighCategory: Health NewsCreated: 3/10/2010 8:48:00 AMLast Editorial Review: 3/10/2010 8:48:30 AM (Source: MedicineNet HIV General)

Title: CDC: Genital Herpes Rates Still HighCategory: Health NewsCreated: 3/10/2010 8:48:00 AMLast Editorial Review: 3/10/2010 8:48:30 AM (Source: MedicineNet Womens Health General)

CDC: Genital Herpes Rates Still High (Source: eMedicineHealth.com)

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Molecular dermatology research and development innovator DermaGenoma, Inc. released The HerpesDX Genetic Test for Frequent Genital Herpes. The new screening test will help doctors assess patients' risk for developing frequent Genital Herpes (HSV-2) outbreaks. "Until now, physicians have been unable to give patients an answer to the most common question asked by recently infected Genital Herpes patients: Will I have frequent outbreaks?," says DermaGenoma CEO Andy Goren. "Using the HerpesDX genetic test, a doctor can finally assess a patient's risk for frequent outbreaks... (Source: Health News from Medical News Today)

Molecular dermatology research and development innovator DermaGenoma, Inc. released The HerpesDX Genetic Test for Frequent Genital Herpes. The new screening test will help doctors assess patients' risk for developing frequent Genital Herpes (HSV-2) outbreaks... (Source: Sexual Health / STDs News From Medical News Today)

We describe herein the clinical courses and outcomes of 26 patients who received oral mycophenolate mofetil (MMF) for the treatment of steroid-resistant refractory or steroid-dependent acute or chronic graft-versus-host disease (GVHD) in a single institution. In most cases, 1,500 mg/day of MMF is a median dose (range 500-3,000 mg/day) and administered for 116.5 days (range 9-584 days) along with calcineurin inhibitors and steroids. Although 20 patients (77%) showed rapid improvement of GVHD symptoms, of 15 patients, 13 (87%) showed acute GVHD; of 11 patients, 7 (64%) showed chronic GVHD; most patients (54%) experienced infection during MMF administration, including 5 cases with life-threatening infection. Positive cytomegalovirus (CMV) antigenemia was also observed in 19 patients (73%), bu...

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We followed up 550 primary kidney transplant recipients in an observational retrospective cohort to evaluate the impact of three consecutive cytomegalovirus (CMV) prevention strategies. In period 1 (1996[ndash]2000; n = 190), no anti-CMV prophylaxis was given; in period 2 (2000[ndash]2004; n = 173), 6-month valacyclovir was given and in period 3 (>2004; n = 187), 6-month valganciclovir was given. Cytomegalovirus disease significantly decreased from 33.2% in period 1 to 13.9% in period 2 and to 8.6% in period 3; onset was significantly prolonged with valganciclovir (228 days) compared with valacyclovir (93 days) and with no prophylaxis (33 days). After Cox regression adjustments, both valganciclovir and valacyclovir were similarly protective factors for CMV disease. Cytomegalovirus diseases...

In this study the prevalences of Epstein–Barr virus (EBV), herpes simplex virus type 1 (HSV-1), HSV-2, cytomegalovirus (CMV), adenovirus, Chlamydia trachomatis, Mycoplasma genitalium and Ureaplasma urealyticum (including subtyping) were investigated. Samples from 112 male STI attendants with microscopically verified urethritis and from a control group of 103 men without clinical or microscopic signs of urethritis were analysed. Prevalences in the urethritis group compared with the controls were as follows: EBV 21%, 6% (P < 0.01); C. trachomatis 15%, 3% (P < 0.01); M. genitalium 6%, 1% (P = 0.067) and U. urealyticum 10%, 10% (ns). The results for HSV-1, HSV-2, CMV and adenovirus were negative in patients, and therefore not analysed in the controls. EBV was shown to be an indepen...

Disseminated mucocutaneous herpes simplex virus (HSV) infection in an immunocompetent person is quite rare. A 19-year-old healthy Japanese woman presented with painful, umbilicated vesicles and pustules on her genital region, both nipples and on the forearm 10 days after the last sexual contact with her partner who had cold sore at that time. Tzanck test and biopsy confirmed the diagnosis of disseminated mucocutaneous HSV infection. She did not have any visceral HSV disease. Skin lesions improved after treatment with acyclovir and erythromycin for seven days. We propose that like herpes gladiatorum, HSV dissemination in this case was acquired by close body contact. (Source: International Journal of STD and AIDS)

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WASHINGTON (Reuters) - About 16 percent of Americans between the ages of 14 and 49 are infected with genital herpes, making it one of the most common sexually transmitted diseases, U.S. health officials said on Tuesday. (Source: Reuters: Health)